Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Abstract Objectives The main aim of the research was to analyze an economical and eco-friendly approach improve solubility norfloxacin. current analysis utilize hydrotropic solutions extract drugs from their dosage forms, avoiding use costlier harmful organic solvents. Materials Methods In this study, ultraviolet–visible spectrophotometer (model 1800, Shimadzu Corporation) used norfloxacin drug. mixed hydrotropy determine work, a blend solution (20% urea + 20% sodium benzoate) as solubilizing agent. Results drug in water very low at ∼0.88 mg/mL 11 mg/mL. From 98.96 (tablet II) 99.35 I), percent estimation value achieved. This nearly 100, so proposed method correct. Standard deviation (0.2540–0.4156), percentage coefficient variation (0.2566–0.4183), standard error (0.1481–0.2415) are also low; hence, we can say that is accurate. Conclusion To avoid solvents, concept be for spectrophotometric water-soluble bulk samples. It provides environmentally friendly mechanism.